| Edwardsville to Orangevale (California) | 1,674.96 mi (2,695.59 km) |
| Edwardsville to Orchards (Washington) | 1,718.25 mi (2,765.26 km) |
| Edwardsville to Orcutt (California) | 1,696.81 mi (2,730.75 km) |
| Edwardsville to Oregon (Ohio) | 398.15 mi (640.75 km) |
| Edwardsville to Oregon (Wisconsin) | 287.27 mi (462.32 km) |
| Edwardsville to Oregon City (Oregon) | 1,719.55 mi (2,767.34 km) |
| Edwardsville to Orem (Utah) | 1,158.56 mi (1,864.51 km) |
| Edwardsville to Orinda (California) | 1,736.74 mi (2,795.01 km) |
| Edwardsville to Orland Park (Illinois) | 224.52 mi (361.34 km) |
| Edwardsville to Orlando (Florida) | 868.25 mi (1,397.31 km) |
| Edwardsville to Ormond Beach (Florida) | 829.16 mi (1,334.40 km) |
| Edwardsville to Oro Valley (Arizona) | 1,255.02 mi (2,019.76 km) |
| Edwardsville to Oroville (California) | 1,683.99 mi (2,710.11 km) |
| Edwardsville to Oshkosh (Wisconsin) | 368.85 mi (593.60 km) |
| Edwardsville to Oskaloosa (Iowa) | 222.53 mi (358.12 km) |
