| Edwardsville to Olympia Heights (Florida) | 1,062.94 mi (1,710.64 km) |
| Edwardsville to Omaha (Nebraska) | 363.36 mi (584.77 km) |
| Edwardsville to On Top of the World Designated Place (Florida) | 800.96 mi (1,289.02 km) |
| Edwardsville to Onalaska (Wisconsin) | 357.74 mi (575.72 km) |
| Edwardsville to Oneida (New York) | 802.90 mi (1,292.14 km) |
| Edwardsville to Oneonta (New York) | 821.08 mi (1,321.41 km) |
| Edwardsville to Ontario (California) | 1,564.04 mi (2,517.08 km) |
| Edwardsville to Ontario (Oregon) | 1,437.44 mi (2,313.34 km) |
| Edwardsville to Opa-locka (Florida) | 1,054.99 mi (1,697.84 km) |
| Edwardsville to Opelika (Alabama) | 496.13 mi (798.45 km) |
| Edwardsville to Opelousas (Louisiana) | 583.41 mi (938.91 km) |
| Edwardsville to Orange (California) | 1,581.29 mi (2,544.84 km) |
| Edwardsville to Orange (Texas) | 636.24 mi (1,023.94 km) |
| Edwardsville to Orange City (Florida) | 843.43 mi (1,357.37 km) |
| Edwardsville to Orangeburg (South Carolina) | 626.38 mi (1,008.07 km) |
