| Edwardsville to Odessa (Texas) | 843.27 mi (1,357.12 km) |
| Edwardsville to Ogden (Utah) | 1,172.14 mi (1,886.38 km) |
| Edwardsville to Oildale (California) | 1,610.17 mi (2,591.32 km) |
| Edwardsville to Ojus (Florida) | 1,054.56 mi (1,697.15 km) |
| Edwardsville to Okemos (Michigan) | 397.62 mi (639.91 km) |
| Edwardsville to Oklahoma City (Oklahoma) | 473.74 mi (762.41 km) |
| Edwardsville to Okmulgee (Oklahoma) | 397.32 mi (639.42 km) |
| Edwardsville to Olathe (Kansas) | 260.13 mi (418.64 km) |
| Edwardsville to Old Jamestown (Missouri) | 16.33 mi (26.29 km) |
| Edwardsville to Oldsmar (Florida) | 853.01 mi (1,372.78 km) |
| Edwardsville to Olean (New York) | 648.14 mi (1,043.07 km) |
| Edwardsville to Olive Branch (Mississippi) | 264.82 mi (426.19 km) |
| Edwardsville to Olivehurst (California) | 1,688.15 mi (2,716.82 km) |
| Edwardsville to Olney (Maryland) | 693.67 mi (1,116.36 km) |
| Edwardsville to Olympia (Washington) | 1,744.90 mi (2,808.14 km) |
