| Edwardsville to Oakley (California) | 1,709.34 mi (2,750.92 km) |
| Edwardsville to Oakton (Virginia) | 682.19 mi (1,097.87 km) |
| Edwardsville to Oakville (Missouri) | 29.80 mi (47.96 km) |
| Edwardsville to Oatfield (Oregon) | 1,719.94 mi (2,767.98 km) |
| Edwardsville to Ocala (Florida) | 801.00 mi (1,289.09 km) |
| Edwardsville to Ocean Acres (New Jersey) | 841.67 mi (1,354.54 km) |
| Edwardsville to Ocean City (New Jersey) | 825.44 mi (1,328.41 km) |
| Edwardsville to Ocean Pines (Maryland) | 801.00 mi (1,289.08 km) |
| Edwardsville to Ocean Pointe (Hawaii) | 4,149.06 mi (6,677.27 km) |
| Edwardsville to Ocean Springs (Mississippi) | 583.28 mi (938.69 km) |
| Edwardsville to Oceanside (California) | 1,568.29 mi (2,523.91 km) |
| Edwardsville to Oceanside (New York) | 877.01 mi (1,411.42 km) |
| Edwardsville to Ocoee (Florida) | 855.89 mi (1,377.43 km) |
| Edwardsville to Oconomowoc (Wisconsin) | 307.62 mi (495.07 km) |
| Edwardsville to Odenton (Maryland) | 714.14 mi (1,149.29 km) |
