| Edwardsville to Newport East (Rhode Island) | 1,003.19 mi (1,614.48 km) |
| Edwardsville to Newport News (Virginia) | 742.34 mi (1,194.68 km) |
| Edwardsville to Newton (Iowa) | 257.23 mi (413.96 km) |
| Edwardsville to Newton (Kansas) | 401.61 mi (646.32 km) |
| Edwardsville to Newton (Massachusetts) | 1,013.29 mi (1,630.73 km) |
| Edwardsville to Newton (North Carolina) | 527.59 mi (849.08 km) |
| Edwardsville to Niagara Falls (New York) | 644.43 mi (1,037.11 km) |
| Edwardsville to Niceville (Florida) | 604.68 mi (973.14 km) |
| Edwardsville to Nicholasville (Kentucky) | 300.24 mi (483.18 km) |
| Edwardsville to Niles (Illinois) | 251.18 mi (404.23 km) |
| Edwardsville to Niles (Michigan) | 288.06 mi (463.59 km) |
| Edwardsville to Niles (Ohio) | 515.78 mi (830.07 km) |
| Edwardsville to Nipomo (California) | 1,697.43 mi (2,731.76 km) |
| Edwardsville to Nixa (Missouri) | 216.98 mi (349.19 km) |
| Edwardsville to Noblesville (Indiana) | 229.29 mi (369.01 km) |
