| Edwardsville to Medford (New York) | 911.74 mi (1,467.31 km) |
| Edwardsville to Medford (Oregon) | 1,731.46 mi (2,786.52 km) |
| Edwardsville to Medina (Ohio) | 459.15 mi (738.94 km) |
| Edwardsville to Medulla (Florida) | 878.64 mi (1,414.03 km) |
| Edwardsville to Mehlville (Missouri) | 26.74 mi (43.03 km) |
| Edwardsville to Melbourne (Florida) | 911.99 mi (1,467.71 km) |
| Edwardsville to Melissa (Texas) | 528.19 mi (850.03 km) |
| Edwardsville to Melrose (Massachusetts) | 1,022.01 mi (1,644.77 km) |
| Edwardsville to Melrose Park (Illinois) | 242.27 mi (389.89 km) |
| Edwardsville to Melville (New York) | 889.50 mi (1,431.51 km) |
| Edwardsville to Melvindale (Michigan) | 430.97 mi (693.58 km) |
| Edwardsville to Memphis (Florida) | 887.19 mi (1,427.80 km) |
| Edwardsville to Memphis (Tennessee) | 254.51 mi (409.59 km) |
| Edwardsville to Menasha (Wisconsin) | 383.09 mi (616.52 km) |
| Edwardsville to Mendota (California) | 1,658.04 mi (2,668.36 km) |
