| Edwardsville to Mauldin (South Carolina) | 507.22 mi (816.29 km) |
| Edwardsville to Maumee (Ohio) | 384.90 mi (619.43 km) |
| Edwardsville to Maumelle (Arkansas) | 303.14 mi (487.86 km) |
| Edwardsville to Mayagüez (Puerto Rico) | 1,975.80 mi (3,179.74 km) |
| Edwardsville to Mayfield Heights (Ohio) | 488.14 mi (785.58 km) |
| Edwardsville to Mays Chapel (Maryland) | 715.65 mi (1,151.72 km) |
| Edwardsville to Maywood (California) | 1,596.50 mi (2,569.32 km) |
| Edwardsville to Maywood (Illinois) | 241.33 mi (388.39 km) |
| Edwardsville to McAlester (Oklahoma) | 416.59 mi (670.44 km) |
| Edwardsville to McAllen (Texas) | 991.64 mi (1,595.89 km) |
| Edwardsville to McCalla (Alabama) | 413.66 mi (665.72 km) |
| Edwardsville to McComb (Mississippi) | 522.23 mi (840.45 km) |
| Edwardsville to McDonough (Georgia) | 492.62 mi (792.79 km) |
| Edwardsville to McFarland (California) | 1,616.57 mi (2,601.62 km) |
| Edwardsville to McHenry (Illinois) | 260.66 mi (419.49 km) |
