| Edwardsville to Lowell (Indiana) | 219.69 mi (353.56 km) |
| Edwardsville to Lowell (Massachusetts) | 1,010.65 mi (1,626.48 km) |
| Edwardsville to Lower Burrell (Pennsylvania) | 559.70 mi (900.75 km) |
| Edwardsville to Lowes Island (Virginia) | 678.90 mi (1,092.58 km) |
| Edwardsville to Lubbock (Texas) | 754.69 mi (1,214.55 km) |
| Edwardsville to Lufkin (Texas) | 581.41 mi (935.69 km) |
| Edwardsville to Luling (Louisiana) | 614.69 mi (989.24 km) |
| Edwardsville to Lumberton (North Carolina) | 671.52 mi (1,080.70 km) |
| Edwardsville to Lumberton (Texas) | 636.61 mi (1,024.52 km) |
| Edwardsville to Lutz (Florida) | 853.99 mi (1,374.36 km) |
| Edwardsville to Lynbrook (New York) | 875.13 mi (1,408.38 km) |
| Edwardsville to Lynchburg (Virginia) | 594.51 mi (956.78 km) |
| Edwardsville to Lynden (Washington) | 1,745.85 mi (2,809.67 km) |
| Edwardsville to Lyndhurst (Ohio) | 486.25 mi (782.54 km) |
| Edwardsville to Lyndon (Kentucky) | 240.49 mi (387.03 km) |
