| Edwardsville to Los Alamos (New Mexico) | 916.10 mi (1,474.32 km) |
| Edwardsville to Los Altos (California) | 1,740.11 mi (2,800.43 km) |
| Edwardsville to Los Angeles (California) | 1,605.31 mi (2,583.50 km) |
| Edwardsville to Los Banos (California) | 1,677.77 mi (2,700.11 km) |
| Edwardsville to Los Gatos (California) | 1,734.80 mi (2,791.90 km) |
| Edwardsville to Los Lunas (New Mexico) | 967.27 mi (1,556.68 km) |
| Edwardsville to Los Osos (California) | 1,709.24 mi (2,750.75 km) |
| Edwardsville to Loudoun Valley Estates (Virginia) | 670.92 mi (1,079.74 km) |
| Edwardsville to Louisville (Colorado) | 812.54 mi (1,307.65 km) |
| Edwardsville to Louisville (Kentucky) | 238.61 mi (384.01 km) |
| Edwardsville to Lovejoy (Georgia) | 486.36 mi (782.72 km) |
| Edwardsville to Loveland (Colorado) | 809.29 mi (1,302.43 km) |
| Edwardsville to Loveland (Ohio) | 308.39 mi (496.31 km) |
| Edwardsville to Loves Park (Illinois) | 250.33 mi (402.86 km) |
| Edwardsville to Lovington (New Mexico) | 849.13 mi (1,366.54 km) |
