| Edwardsville to Lewiston (Maine) | 1,086.59 mi (1,748.70 km) |
| Edwardsville to Lewisville (North Carolina) | 556.57 mi (895.71 km) |
| Edwardsville to Lewisville (Texas) | 557.16 mi (896.66 km) |
| Edwardsville to Lexington (Kentucky) | 303.70 mi (488.75 km) |
| Edwardsville to Lexington (Nebraska) | 535.67 mi (862.07 km) |
| Edwardsville to Lexington (North Carolina) | 572.40 mi (921.18 km) |
| Edwardsville to Lexington (South Carolina) | 589.40 mi (948.54 km) |
| Edwardsville to Lexington Park (Maryland) | 732.47 mi (1,178.79 km) |
| Edwardsville to Liberal (Kansas) | 608.08 mi (978.62 km) |
| Edwardsville to Liberty (Missouri) | 239.88 mi (386.05 km) |
| Edwardsville to Liberty Lake (Washington) | 1,486.44 mi (2,392.19 km) |
| Edwardsville to Liberty Triangle (Florida) | 804.84 mi (1,295.27 km) |
| Edwardsville to Libertyville (Illinois) | 263.72 mi (424.42 km) |
| Edwardsville to Lighthouse Point (Florida) | 1,037.69 mi (1,670.01 km) |
| Edwardsville to Lilburn (Georgia) | 469.65 mi (755.84 km) |
