| Edwardsville to Iselin (New Jersey) | 841.11 mi (1,353.64 km) |
| Edwardsville to Isla Vista (California) | 1,676.70 mi (2,698.39 km) |
| Edwardsville to Issaquah (Washington) | 1,710.28 mi (2,752.43 km) |
| Edwardsville to Ithaca (New York) | 749.85 mi (1,206.76 km) |
| Edwardsville to Ives Estates (Florida) | 1,053.45 mi (1,695.36 km) |
| Edwardsville to Jackson (Michigan) | 377.83 mi (608.05 km) |
| Edwardsville to Jackson (Mississippi) | 447.66 mi (720.44 km) |
| Edwardsville to Jackson (Missouri) | 99.32 mi (159.83 km) |
| Edwardsville to Jackson (Tennessee) | 225.91 mi (363.57 km) |
| Edwardsville to Jackson (Wyoming) | 1,125.64 mi (1,811.55 km) |
| Edwardsville to Jacksonville (Alabama) | 417.15 mi (671.33 km) |
| Edwardsville to Jacksonville (Arkansas) | 295.07 mi (474.87 km) |
| Edwardsville to Jacksonville (Florida) | 751.18 mi (1,208.90 km) |
| Edwardsville to Jacksonville (Illinois) | 66.05 mi (106.29 km) |
| Edwardsville to Jacksonville (North Carolina) | 750.67 mi (1,208.08 km) |
