| Edwardsville to Indianola (Iowa) | 259.43 mi (417.51 km) |
| Edwardsville to Indio (California) | 1,497.80 mi (2,410.47 km) |
| Edwardsville to Inglewood (California) | 1,605.69 mi (2,584.11 km) |
| Edwardsville to Inkster (Michigan) | 425.54 mi (684.84 km) |
| Edwardsville to Inver Grove Heights (Minnesota) | 445.73 mi (717.34 km) |
| Edwardsville to Inwood (New York) | 870.99 mi (1,401.73 km) |
| Edwardsville to Iona (Florida) | 967.23 mi (1,556.61 km) |
| Edwardsville to Ionia (Michigan) | 386.54 mi (622.07 km) |
| Edwardsville to Iowa City (Iowa) | 213.94 mi (344.30 km) |
| Edwardsville to Irmo (South Carolina) | 585.90 mi (942.91 km) |
| Edwardsville to Irondale (Alabama) | 407.26 mi (655.43 km) |
| Edwardsville to Ironton (Ohio) | 394.66 mi (635.14 km) |
| Edwardsville to Irvine (California) | 1,581.81 mi (2,545.68 km) |
| Edwardsville to Irving (Texas) | 566.31 mi (911.38 km) |
| Edwardsville to Isabela (Puerto Rico) | 1,964.77 mi (3,161.98 km) |
