| Edwardsville to Hutchinson (Minnesota) | 477.62 mi (768.66 km) |
| Edwardsville to Hutto (Texas) | 713.21 mi (1,147.80 km) |
| Edwardsville to Hyattsville (Maryland) | 700.51 mi (1,127.36 km) |
| Edwardsville to Hybla Valley (Virginia) | 694.63 mi (1,117.90 km) |
| Edwardsville to Idaho Falls (Idaho) | 1,188.29 mi (1,912.37 km) |
| Edwardsville to Idylwood (Virginia) | 687.34 mi (1,106.16 km) |
| Edwardsville to Ilchester (Maryland) | 709.73 mi (1,142.21 km) |
| Edwardsville to Immokalee (Florida) | 988.02 mi (1,590.06 km) |
| Edwardsville to Imperial (California) | 1,485.74 mi (2,391.06 km) |
| Edwardsville to Imperial Beach (California) | 1,575.63 mi (2,535.73 km) |
| Edwardsville to Independence (Kentucky) | 292.70 mi (471.05 km) |
| Edwardsville to Independence (Missouri) | 235.32 mi (378.71 km) |
| Edwardsville to Indian Trail (North Carolina) | 576.11 mi (927.17 km) |
| Edwardsville to Indiana (Pennsylvania) | 589.09 mi (948.04 km) |
| Edwardsville to Indianapolis (Indiana) | 216.40 mi (348.26 km) |
