| Edwardsville to Euless (Texas) | 570.95 mi (918.85 km) |
| Edwardsville to Eureka (California) | 1,807.77 mi (2,909.32 km) |
| Edwardsville to Eureka (Missouri) | 41.01 mi (65.99 km) |
| Edwardsville to Eustis (Florida) | 835.08 mi (1,343.93 km) |
| Edwardsville to Evans (Colorado) | 792.11 mi (1,274.78 km) |
| Edwardsville to Evans (Georgia) | 567.39 mi (913.13 km) |
| Edwardsville to Evanston (Illinois) | 255.13 mi (410.59 km) |
| Edwardsville to Evanston (Wyoming) | 1,120.07 mi (1,802.58 km) |
| Edwardsville to Evansville (Indiana) | 144.00 mi (231.75 km) |
| Edwardsville to Everett (Massachusetts) | 1,021.77 mi (1,644.38 km) |
| Edwardsville to Everett (Washington) | 1,720.30 mi (2,768.56 km) |
| Edwardsville to Evergreen Park (Illinois) | 235.54 mi (379.06 km) |
| Edwardsville to Ewa Beach (Hawaii) | 4,147.77 mi (6,675.19 km) |
| Edwardsville to Ewa Gentry (Hawaii) | 4,148.16 mi (6,675.82 km) |
| Edwardsville to Excelsior Springs (Missouri) | 231.22 mi (372.11 km) |
