| Edwardsville to Enumclaw (Washington) | 1,704.12 mi (2,742.52 km) |
| Edwardsville to Ephrata (Pennsylvania) | 741.66 mi (1,193.59 km) |
| Edwardsville to Erie (Colorado) | 807.11 mi (1,298.92 km) |
| Edwardsville to Erie (Pennsylvania) | 569.14 mi (915.93 km) |
| Edwardsville to Erlanger (Kentucky) | 290.76 mi (467.94 km) |
| Edwardsville to Escanaba (Michigan) | 502.80 mi (809.17 km) |
| Edwardsville to Escondido (California) | 1,557.99 mi (2,507.34 km) |
| Edwardsville to Española (New Mexico) | 902.18 mi (1,451.93 km) |
| Edwardsville to Essex (Maryland) | 726.86 mi (1,169.77 km) |
| Edwardsville to Essex Junction (Vermont) | 953.69 mi (1,534.82 km) |
| Edwardsville to Estelle (Louisiana) | 618.25 mi (994.97 km) |
| Edwardsville to Estero (Florida) | 977.29 mi (1,572.80 km) |
| Edwardsville to Euclid (Ohio) | 486.71 mi (783.28 km) |
| Edwardsville to Eufaula (Alabama) | 547.87 mi (881.71 km) |
| Edwardsville to Eugene (Oregon) | 1,742.13 mi (2,803.68 km) |
