| Edwardsville to Emeryville (California) | 1,743.45 mi (2,805.81 km) |
| Edwardsville to Emmaus (Pennsylvania) | 779.11 mi (1,253.86 km) |
| Edwardsville to Emporia (Kansas) | 336.12 mi (540.94 km) |
| Edwardsville to Encinitas (California) | 1,570.34 mi (2,527.22 km) |
| Edwardsville to Endicott (New York) | 765.89 mi (1,232.58 km) |
| Edwardsville to Endwell (New York) | 768.30 mi (1,236.46 km) |
| Edwardsville to Englewood (Colorado) | 804.52 mi (1,294.75 km) |
| Edwardsville to Englewood (Florida) | 928.24 mi (1,493.86 km) |
| Edwardsville to Englewood (New Jersey) | 860.57 mi (1,384.96 km) |
| Edwardsville to Englewood (Ohio) | 312.44 mi (502.82 km) |
| Edwardsville to Enid (Oklahoma) | 461.73 mi (743.08 km) |
| Edwardsville to Ennis (Texas) | 582.08 mi (936.77 km) |
| Edwardsville to Ensley (Florida) | 591.52 mi (951.96 km) |
| Edwardsville to Enterprise (Alabama) | 566.27 mi (911.32 km) |
| Edwardsville to Enterprise (Nevada) | 1,394.17 mi (2,243.70 km) |
