| Edwardsville to El Sobrante (California) | 1,560.31 mi (2,511.08 km) |
| Edwardsville to Eldersburg (Maryland) | 699.60 mi (1,125.89 km) |
| Edwardsville to Elfers (Florida) | 841.51 mi (1,354.27 km) |
| Edwardsville to Elgin (Illinois) | 240.74 mi (387.43 km) |
| Edwardsville to Elizabeth (New Jersey) | 848.11 mi (1,364.89 km) |
| Edwardsville to Elizabeth City (North Carolina) | 772.05 mi (1,242.50 km) |
| Edwardsville to Elizabethton (Tennessee) | 456.93 mi (735.36 km) |
| Edwardsville to Elizabethtown (Kentucky) | 235.35 mi (378.76 km) |
| Edwardsville to Elizabethtown (Pennsylvania) | 719.53 mi (1,157.98 km) |
| Edwardsville to Elk City (Oklahoma) | 570.79 mi (918.59 km) |
| Edwardsville to Elk Grove (California) | 1,687.05 mi (2,715.05 km) |
| Edwardsville to Elk Grove Village (Illinois) | 245.63 mi (395.30 km) |
| Edwardsville to Elk Plain (Washington) | 1,720.17 mi (2,768.34 km) |
| Edwardsville to Elk River (Minnesota) | 487.57 mi (784.66 km) |
| Edwardsville to Elkhart (Indiana) | 291.80 mi (469.61 km) |
