| Edwardsville to Eggertsville (New York) | 650.69 mi (1,047.19 km) |
| Edwardsville to Egypt Lake-Leto (Florida) | 859.68 mi (1,383.52 km) |
| Edwardsville to El Cajon (California) | 1,560.86 mi (2,511.97 km) |
| Edwardsville to El Campo (Texas) | 753.73 mi (1,213.01 km) |
| Edwardsville to El Centro (California) | 1,486.51 mi (2,392.31 km) |
| Edwardsville to El Cerrito (California) | 1,742.76 mi (2,804.70 km) |
| Edwardsville to El Dorado (Arkansas) | 413.09 mi (664.81 km) |
| Edwardsville to El Dorado (Kansas) | 378.58 mi (609.27 km) |
| Edwardsville to El Dorado Hills (California) | 1,665.99 mi (2,681.15 km) |
| Edwardsville to El Mirage (Arizona) | 1,292.77 mi (2,080.51 km) |
| Edwardsville to El Monte (California) | 1,585.95 mi (2,552.33 km) |
| Edwardsville to El Paso (Texas) | 1,041.57 mi (1,676.25 km) |
| Edwardsville to El Paso de Robles (California) | 1,693.48 mi (2,725.39 km) |
| Edwardsville to El Reno (Oklahoma) | 493.08 mi (793.53 km) |
| Edwardsville to El Segundo (California) | 1,609.72 mi (2,590.60 km) |
