| Edwardsville to East Providence (Rhode Island) | 1,001.49 mi (1,611.74 km) |
| Edwardsville to East Rancho Dominguez (California) | 1,599.17 mi (2,573.62 km) |
| Edwardsville to East Renton Highlands (Washington) | 1,711.29 mi (2,754.05 km) |
| Edwardsville to East Ridge (Tennessee) | 371.24 mi (597.45 km) |
| Edwardsville to East Riverdale (Maryland) | 702.87 mi (1,131.16 km) |
| Edwardsville to East San Gabriel (California) | 1,587.65 mi (2,555.07 km) |
| Edwardsville to East St. Louis (Illinois) | 14.44 mi (23.24 km) |
| Edwardsville to East Wenatchee (Washington) | 1,627.56 mi (2,619.31 km) |
| Edwardsville to Eastern Goleta Valley (California) | 1,672.02 mi (2,690.86 km) |
| Edwardsville to Eastlake (Ohio) | 492.55 mi (792.68 km) |
| Edwardsville to Eastmont (Washington) | 1,720.35 mi (2,768.63 km) |
| Edwardsville to Easton (Maryland) | 748.85 mi (1,205.15 km) |
| Edwardsville to Easton (Pennsylvania) | 794.40 mi (1,278.46 km) |
| Edwardsville to Eastpointe (Michigan) | 447.81 mi (720.67 km) |
| Edwardsville to Eastvale (California) | 1,564.49 mi (2,517.81 km) |
