| Edwardsville to Eagan (Minnesota) | 447.17 mi (719.65 km) |
| Edwardsville to Eagle (Idaho) | 1,406.35 mi (2,263.30 km) |
| Edwardsville to Eagle Mountain (Utah) | 1,174.95 mi (1,890.90 km) |
| Edwardsville to Eagle Pass (Texas) | 919.85 mi (1,480.36 km) |
| Edwardsville to Easley (South Carolina) | 492.86 mi (793.18 km) |
| Edwardsville to East Bakersfield (California) | 1,608.07 mi (2,587.94 km) |
| Edwardsville to East Bethel (Minnesota) | 482.45 mi (776.44 km) |
| Edwardsville to East Chicago (Indiana) | 238.22 mi (383.38 km) |
| Edwardsville to East Cleveland (Ohio) | 482.36 mi (776.28 km) |
| Edwardsville to East Glenville (New York) | 883.95 mi (1,422.59 km) |
| Edwardsville to East Grand Rapids (Michigan) | 366.93 mi (590.52 km) |
| Edwardsville to East Hemet (California) | 1,535.80 mi (2,471.63 km) |
| Edwardsville to East Highland Park (Virginia) | 688.91 mi (1,108.70 km) |
| Edwardsville to East Honolulu (Hawaii) | 4,133.18 mi (6,651.71 km) |
| Edwardsville to East Islip (New York) | 900.87 mi (1,449.82 km) |
