| Edwardsville to Duluth (Minnesota) | 562.23 mi (904.82 km) |
| Edwardsville to Dumas (Texas) | 687.88 mi (1,107.03 km) |
| Edwardsville to Dumont (New Jersey) | 859.90 mi (1,383.87 km) |
| Edwardsville to Duncan (Oklahoma) | 528.48 mi (850.51 km) |
| Edwardsville to Duncanville (Texas) | 575.17 mi (925.65 km) |
| Edwardsville to Dundalk (Maryland) | 724.29 mi (1,165.63 km) |
| Edwardsville to Dunedin (Florida) | 850.82 mi (1,369.26 km) |
| Edwardsville to Dunkirk (New York) | 613.44 mi (987.23 km) |
| Edwardsville to Dunmore (Pennsylvania) | 780.27 mi (1,255.72 km) |
| Edwardsville to Dunwoody (Georgia) | 460.24 mi (740.69 km) |
| Edwardsville to Durango (Colorado) | 977.81 mi (1,573.63 km) |
| Edwardsville to Durant (Oklahoma) | 486.33 mi (782.68 km) |
| Edwardsville to Durham (North Carolina) | 638.36 mi (1,027.34 km) |
| Edwardsville to Dyer (Indiana) | 228.18 mi (367.22 km) |
| Edwardsville to Dyersburg (Tennessee) | 192.64 mi (310.02 km) |
