| Edwardsville to Des Plaines (Illinois) | 249.45 mi (401.45 km) |
| Edwardsville to Desert Hot Springs (California) | 1,508.93 mi (2,428.40 km) |
| Edwardsville to DeSoto (Texas) | 575.78 mi (926.63 km) |
| Edwardsville to Destin (Florida) | 613.57 mi (987.44 km) |
| Edwardsville to Destrehan (Louisiana) | 610.45 mi (982.42 km) |
| Edwardsville to Detroit (Michigan) | 438.03 mi (704.94 km) |
| Edwardsville to Diamond Bar (California) | 1,576.27 mi (2,536.76 km) |
| Edwardsville to Diamond Springs (California) | 1,654.64 mi (2,662.89 km) |
| Edwardsville to Dickinson (North Dakota) | 854.81 mi (1,375.69 km) |
| Edwardsville to Dickinson (Texas) | 707.04 mi (1,137.87 km) |
| Edwardsville to Dickson (Tennessee) | 237.08 mi (381.55 km) |
| Edwardsville to Difficult Run (Virginia) | 679.69 mi (1,093.86 km) |
| Edwardsville to Dinuba (California) | 1,609.06 mi (2,589.54 km) |
| Edwardsville to Discovery Bay (California) | 1,705.44 mi (2,744.65 km) |
| Edwardsville to Dix Hills (New York) | 893.31 mi (1,437.65 km) |
