| Edwardsville to Delaware (Ohio) | 382.42 mi (615.45 km) |
| Edwardsville to Delhi (California) | 1,668.51 mi (2,685.21 km) |
| Edwardsville to Delray Beach (Florida) | 1,027.23 mi (1,653.17 km) |
| Edwardsville to Deltona (Florida) | 847.65 mi (1,364.17 km) |
| Edwardsville to Deming (New Mexico) | 1,093.59 mi (1,759.96 km) |
| Edwardsville to Denison (Texas) | 505.11 mi (812.89 km) |
| Edwardsville to Dent (Ohio) | 287.37 mi (462.48 km) |
| Edwardsville to Denton (Texas) | 554.86 mi (892.97 km) |
| Edwardsville to Dentsville (South Carolina) | 598.14 mi (962.61 km) |
| Edwardsville to Denver (Colorado) | 798.19 mi (1,284.56 km) |
| Edwardsville to Depew (New York) | 654.04 mi (1,052.58 km) |
| Edwardsville to Derby (Connecticut) | 909.37 mi (1,463.49 km) |
| Edwardsville to Derby (Kansas) | 403.75 mi (649.78 km) |
| Edwardsville to Des Moines (Iowa) | 271.02 mi (436.17 km) |
| Edwardsville to Des Moines (Washington) | 1,721.11 mi (2,769.86 km) |
