| Edwardsville to Decatur (Alabama) | 335.44 mi (539.84 km) |
| Edwardsville to Decatur (Georgia) | 469.72 mi (755.94 km) |
| Edwardsville to Decatur (Illinois) | 92.56 mi (148.97 km) |
| Edwardsville to Deer Park (New York) | 893.96 mi (1,438.70 km) |
| Edwardsville to Deer Park (Texas) | 693.44 mi (1,115.99 km) |
| Edwardsville to Deerfield (Illinois) | 258.66 mi (416.28 km) |
| Edwardsville to Deerfield Beach (Florida) | 1,034.89 mi (1,665.50 km) |
| Edwardsville to Defiance (Ohio) | 343.43 mi (552.70 km) |
| Edwardsville to DeForest (Wisconsin) | 308.46 mi (496.42 km) |
| Edwardsville to DeKalb (Illinois) | 226.49 mi (364.50 km) |
| Edwardsville to Del Aire (California) | 1,607.98 mi (2,587.80 km) |
| Edwardsville to Del City (Oklahoma) | 470.94 mi (757.90 km) |
| Edwardsville to Del Rio (Texas) | 899.92 mi (1,448.28 km) |
| Edwardsville to DeLand (Florida) | 838.43 mi (1,349.32 km) |
| Edwardsville to Delano (California) | 1,616.06 mi (2,600.79 km) |
