| Edwardsville to Darby (Pennsylvania) | 789.69 mi (1,270.88 km) |
| Edwardsville to Dardenne Prairie (Missouri) | 40.18 mi (64.66 km) |
| Edwardsville to Darien (Illinois) | 229.75 mi (369.75 km) |
| Edwardsville to Davenport (Iowa) | 193.76 mi (311.82 km) |
| Edwardsville to Davidson (North Carolina) | 553.68 mi (891.06 km) |
| Edwardsville to Davie (Florida) | 1,043.29 mi (1,679.01 km) |
| Edwardsville to Davis (California) | 1,704.02 mi (2,742.35 km) |
| Edwardsville to Dayton (Nevada) | 1,580.85 mi (2,544.13 km) |
| Edwardsville to Dayton (Ohio) | 316.86 mi (509.94 km) |
| Edwardsville to Daytona Beach (Florida) | 834.86 mi (1,343.57 km) |
| Edwardsville to De Pere (Wisconsin) | 401.84 mi (646.70 km) |
| Edwardsville to De Witt (New York) | 781.69 mi (1,258.01 km) |
| Edwardsville to Dearborn (Michigan) | 430.65 mi (693.06 km) |
| Edwardsville to Dearborn Heights (Michigan) | 428.03 mi (688.84 km) |
| Edwardsville to DeBary (Florida) | 845.29 mi (1,360.36 km) |
