| Edwardsville to Crawfordsville (Indiana) | 186.17 mi (299.62 km) |
| Edwardsville to Crest Hill (Illinois) | 216.07 mi (347.73 km) |
| Edwardsville to Crestview (Florida) | 588.40 mi (946.94 km) |
| Edwardsville to Crestwood (Illinois) | 230.03 mi (370.20 km) |
| Edwardsville to Crestwood (Missouri) | 26.63 mi (42.85 km) |
| Edwardsville to Creve Coeur (Missouri) | 26.15 mi (42.09 km) |
| Edwardsville to Crofton (Maryland) | 715.05 mi (1,150.76 km) |
| Edwardsville to Crossville (Tennessee) | 335.48 mi (539.90 km) |
| Edwardsville to Crowley (Louisiana) | 607.78 mi (978.13 km) |
| Edwardsville to Crowley (Texas) | 595.78 mi (958.82 km) |
| Edwardsville to Crown Point (Indiana) | 228.69 mi (368.05 km) |
| Edwardsville to Crystal (Minnesota) | 464.94 mi (748.25 km) |
| Edwardsville to Crystal Lake (Illinois) | 253.09 mi (407.31 km) |
| Edwardsville to Cudahy (California) | 1,596.86 mi (2,569.89 km) |
| Edwardsville to Cudahy (Wisconsin) | 307.71 mi (495.21 km) |
