| Edwardsville to Cordele (Georgia) | 587.70 mi (945.81 km) |
| Edwardsville to Corinth (Mississippi) | 277.84 mi (447.13 km) |
| Edwardsville to Corinth (Texas) | 555.62 mi (894.19 km) |
| Edwardsville to Cornelius (North Carolina) | 551.21 mi (887.09 km) |
| Edwardsville to Cornelius (Oregon) | 1,742.52 mi (2,804.31 km) |
| Edwardsville to Corning (New York) | 717.27 mi (1,154.34 km) |
| Edwardsville to Corona (California) | 1,566.08 mi (2,520.36 km) |
| Edwardsville to Coronado (California) | 1,575.27 mi (2,535.15 km) |
| Edwardsville to Corpus Christi (Texas) | 874.97 mi (1,408.12 km) |
| Edwardsville to Corsicana (Texas) | 589.51 mi (948.73 km) |
| Edwardsville to Cortland (New York) | 768.65 mi (1,237.02 km) |
| Edwardsville to Corvallis (Oregon) | 1,750.66 mi (2,817.42 km) |
| Edwardsville to Coshocton (Ohio) | 445.32 mi (716.68 km) |
| Edwardsville to Costa Mesa (California) | 1,589.58 mi (2,558.18 km) |
| Edwardsville to Coto de Caza (California) | 1,573.75 mi (2,532.70 km) |
