| Edwardsville to Conyers (Georgia) | 486.60 mi (783.10 km) |
| Edwardsville to Cookeville (Tennessee) | 305.93 mi (492.34 km) |
| Edwardsville to Coolidge (Arizona) | 1,268.44 mi (2,041.36 km) |
| Edwardsville to Coon Rapids (Minnesota) | 472.78 mi (760.87 km) |
| Edwardsville to Cooper City (Florida) | 1,045.26 mi (1,682.18 km) |
| Edwardsville to Coos Bay (Oregon) | 1,798.32 mi (2,894.12 km) |
| Edwardsville to Copiague (New York) | 889.93 mi (1,432.21 km) |
| Edwardsville to Coppell (Texas) | 561.66 mi (903.90 km) |
| Edwardsville to Copperas Cove (Texas) | 694.05 mi (1,116.96 km) |
| Edwardsville to Coral Gables (Florida) | 1,066.23 mi (1,715.93 km) |
| Edwardsville to Coral Springs (Florida) | 1,032.77 mi (1,662.09 km) |
| Edwardsville to Coral Terrace (Florida) | 1,062.64 mi (1,710.15 km) |
| Edwardsville to Coralville (Iowa) | 218.02 mi (350.88 km) |
| Edwardsville to Coram (New York) | 910.95 mi (1,466.02 km) |
| Edwardsville to Corcoran (California) | 1,626.07 mi (2,616.90 km) |
