| Edwardsville to Cold Springs (Nevada) | 1,598.52 mi (2,572.57 km) |
| Edwardsville to Coldwater (Michigan) | 341.15 mi (549.03 km) |
| Edwardsville to Colesville (Maryland) | 697.65 mi (1,122.76 km) |
| Edwardsville to College (Alaska) | 2,900.33 mi (4,667.63 km) |
| Edwardsville to College Park (Georgia) | 470.66 mi (757.45 km) |
| Edwardsville to College Park (Maryland) | 701.51 mi (1,128.98 km) |
| Edwardsville to College Station (Texas) | 670.39 mi (1,078.88 km) |
| Edwardsville to Collegedale (Tennessee) | 375.62 mi (604.50 km) |
| Edwardsville to Colleyville (Texas) | 571.55 mi (919.82 km) |
| Edwardsville to Collierville (Tennessee) | 259.26 mi (417.24 km) |
| Edwardsville to Collinsville (Illinois) | 8.02 mi (12.91 km) |
| Edwardsville to Colonia (New Jersey) | 841.33 mi (1,353.99 km) |
| Edwardsville to Colonial Heights (Virginia) | 692.74 mi (1,114.86 km) |
| Edwardsville to Colonial Park (Pennsylvania) | 709.24 mi (1,141.40 km) |
| Edwardsville to Colorado Springs (Colorado) | 794.30 mi (1,278.31 km) |
