| Edwardsville to Cloverleaf (Texas) | 688.61 mi (1,108.21 km) |
| Edwardsville to Cloverly (Maryland) | 697.64 mi (1,122.74 km) |
| Edwardsville to Clovis (California) | 1,619.54 mi (2,606.40 km) |
| Edwardsville to Clovis (New Mexico) | 790.75 mi (1,272.60 km) |
| Edwardsville to Clute (Texas) | 742.32 mi (1,194.64 km) |
| Edwardsville to Coachella (California) | 1,493.98 mi (2,404.34 km) |
| Edwardsville to Coalinga (California) | 1,666.03 mi (2,681.21 km) |
| Edwardsville to Coamo (Puerto Rico) | 2,014.83 mi (3,242.56 km) |
| Edwardsville to Coatesville (Pennsylvania) | 760.19 mi (1,223.41 km) |
| Edwardsville to Cockeysville (Maryland) | 716.80 mi (1,153.58 km) |
| Edwardsville to Cocoa (Florida) | 892.74 mi (1,436.73 km) |
| Edwardsville to Cocoa Beach (Florida) | 900.34 mi (1,448.95 km) |
| Edwardsville to Coconut Creek (Florida) | 1,034.55 mi (1,664.95 km) |
| Edwardsville to Coeur d'Alene (Idaho) | 1,473.10 mi (2,370.73 km) |
| Edwardsville to Cohoes (New York) | 893.32 mi (1,437.66 km) |
