| Edwardsville to Clarksdale (Mississippi) | 319.39 mi (514.01 km) |
| Edwardsville to Clarkston (Georgia) | 469.71 mi (755.93 km) |
| Edwardsville to Clarksville (Indiana) | 230.29 mi (370.62 km) |
| Edwardsville to Clarksville (Tennessee) | 211.00 mi (339.57 km) |
| Edwardsville to Clawson (Michigan) | 441.73 mi (710.89 km) |
| Edwardsville to Clay (Alabama) | 399.25 mi (642.54 km) |
| Edwardsville to Clayton (California) | 1,722.61 mi (2,772.27 km) |
| Edwardsville to Clayton (Missouri) | 21.12 mi (33.99 km) |
| Edwardsville to Clayton (North Carolina) | 670.08 mi (1,078.39 km) |
| Edwardsville to Clayton (Ohio) | 311.35 mi (501.07 km) |
| Edwardsville to Clearfield (Utah) | 1,174.91 mi (1,890.84 km) |
| Edwardsville to Clearlake (California) | 1,746.51 mi (2,810.74 km) |
| Edwardsville to Clearwater (Florida) | 854.80 mi (1,375.66 km) |
| Edwardsville to Cleburne (Texas) | 609.43 mi (980.78 km) |
| Edwardsville to Clemmons (North Carolina) | 560.03 mi (901.27 km) |
