| Edwardsville to Central Point (Oregon) | 1,734.23 mi (2,790.97 km) |
| Edwardsville to Centralia (Illinois) | 50.22 mi (80.81 km) |
| Edwardsville to Centralia (Washington) | 1,745.81 mi (2,809.61 km) |
| Edwardsville to Centreville (Virginia) | 675.03 mi (1,086.35 km) |
| Edwardsville to Ceres (California) | 1,675.98 mi (2,697.23 km) |
| Edwardsville to Cerritos (California) | 1,593.00 mi (2,563.68 km) |
| Edwardsville to Chalco (Nebraska) | 364.82 mi (587.12 km) |
| Edwardsville to Chalmette (Louisiana) | 611.37 mi (983.90 km) |
| Edwardsville to Chambersburg (Pennsylvania) | 662.91 mi (1,066.85 km) |
| Edwardsville to Chamblee (Georgia) | 463.66 mi (746.19 km) |
| Edwardsville to Champaign (Illinois) | 129.23 mi (207.98 km) |
| Edwardsville to Champlin (Minnesota) | 473.95 mi (762.75 km) |
| Edwardsville to Chandler (Arizona) | 1,275.87 mi (2,053.32 km) |
| Edwardsville to Chanhassen (Minnesota) | 457.40 mi (736.12 km) |
| Edwardsville to Channahon (Illinois) | 203.27 mi (327.14 km) |
