| Edwardsville to Castle Pines (Colorado) | 798.16 mi (1,284.51 km) |
| Edwardsville to Castle Rock (Colorado) | 797.41 mi (1,283.31 km) |
| Edwardsville to Castro Valley (California) | 1,733.07 mi (2,789.10 km) |
| Edwardsville to Catalina Foothills (Arizona) | 1,253.77 mi (2,017.74 km) |
| Edwardsville to Cataño (Puerto Rico) | 2,005.08 mi (3,226.87 km) |
| Edwardsville to Cathedral City (California) | 1,507.60 mi (2,426.25 km) |
| Edwardsville to Catonsville (Maryland) | 711.03 mi (1,144.29 km) |
| Edwardsville to Cave Spring (Virginia) | 553.70 mi (891.09 km) |
| Edwardsville to Cayce (South Carolina) | 599.32 mi (964.52 km) |
| Edwardsville to Cayey (Puerto Rico) | 2,021.27 mi (3,252.92 km) |
| Edwardsville to Cedar City (Utah) | 1,253.07 mi (2,016.62 km) |
| Edwardsville to Cedar Falls (Iowa) | 288.12 mi (463.68 km) |
| Edwardsville to Cedar Hill (Texas) | 580.34 mi (933.97 km) |
| Edwardsville to Cedar Lake (Indiana) | 223.28 mi (359.33 km) |
| Edwardsville to Cedar Mill (Oregon) | 1,730.50 mi (2,784.97 km) |
