| Edwardsville to Candler-McAfee (Georgia) | 472.94 mi (761.13 km) |
| Edwardsville to Caño Martin Peña (Puerto Rico) | 2,009.40 mi (3,233.82 km) |
| Edwardsville to Cañon City (Colorado) | 821.75 mi (1,322.47 km) |
| Edwardsville to Canóvanas (Puerto Rico) | 2,019.03 mi (3,249.31 km) |
| Edwardsville to Canton (Georgia) | 437.80 mi (704.58 km) |
| Edwardsville to Canton (Illinois) | 122.40 mi (196.98 km) |
| Edwardsville to Canton (Mississippi) | 428.02 mi (688.83 km) |
| Edwardsville to Canton (Ohio) | 478.05 mi (769.35 km) |
| Edwardsville to Canyon (Texas) | 709.01 mi (1,141.04 km) |
| Edwardsville to Canyon Lake (California) | 1,554.06 mi (2,501.02 km) |
| Edwardsville to Canyon Lake (Texas) | 775.33 mi (1,247.78 km) |
| Edwardsville to Cape Coral (Florida) | 958.33 mi (1,542.28 km) |
| Edwardsville to Cape Girardeau (Missouri) | 104.96 mi (168.92 km) |
| Edwardsville to Carbondale (Illinois) | 84.75 mi (136.40 km) |
| Edwardsville to Carlisle (Pennsylvania) | 687.89 mi (1,107.05 km) |
