| Edwardsville to Blue Island (Illinois) | 232.37 mi (373.96 km) |
| Edwardsville to Blue Springs (Missouri) | 230.87 mi (371.54 km) |
| Edwardsville to Bluffdale (Utah) | 1,170.76 mi (1,884.16 km) |
| Edwardsville to Bluffton (Indiana) | 288.96 mi (465.03 km) |
| Edwardsville to Bluffton (South Carolina) | 682.03 mi (1,097.62 km) |
| Edwardsville to Blythe (California) | 1,414.16 mi (2,275.88 km) |
| Edwardsville to Blytheville (Arkansas) | 197.67 mi (318.11 km) |
| Edwardsville to Boca Raton (Florida) | 1,031.37 mi (1,659.83 km) |
| Edwardsville to Boerne (Texas) | 796.86 mi (1,282.41 km) |
| Edwardsville to Bogalusa (Louisiana) | 553.55 mi (890.85 km) |
| Edwardsville to Boiling Springs (South Carolina) | 512.33 mi (824.52 km) |
| Edwardsville to Boise (Idaho) | 1,397.88 mi (2,249.67 km) |
| Edwardsville to Bolingbrook (Illinois) | 223.54 mi (359.75 km) |
| Edwardsville to Bolivar (Missouri) | 203.47 mi (327.45 km) |
| Edwardsville to Bon Air (Virginia) | 679.75 mi (1,093.95 km) |
