| Edwardsville to Altus (Oklahoma) | 589.46 mi (948.64 km) |
| Edwardsville to Alum Rock (California) | 1,725.51 mi (2,776.94 km) |
| Edwardsville to Alvin (Texas) | 716.90 mi (1,153.74 km) |
| Edwardsville to Amarillo (Texas) | 698.52 mi (1,124.16 km) |
| Edwardsville to Amelia (Ohio) | 310.35 mi (499.47 km) |
| Edwardsville to American Canyon (California) | 1,736.72 mi (2,794.98 km) |
| Edwardsville to American Fork (Utah) | 1,163.43 mi (1,872.36 km) |
| Edwardsville to Americus (Georgia) | 566.04 mi (910.96 km) |
| Edwardsville to Ames (Iowa) | 293.99 mi (473.14 km) |
| Edwardsville to Amherst (Ohio) | 447.67 mi (720.46 km) |
| Edwardsville to Ammon (Idaho) | 1,184.23 mi (1,905.83 km) |
| Edwardsville to Amsterdam (New York) | 872.16 mi (1,403.60 km) |
| Edwardsville to Anacortes (Washington) | 1,747.65 mi (2,812.58 km) |
| Edwardsville to Anaheim (California) | 1,582.35 mi (2,546.54 km) |
| Edwardsville to Anchorage (Alaska) | 2,910.14 mi (4,683.42 km) |
