| Edwardsville to Shoreham-by-Sea | 4,199.38 mi (6,758.24 km) |
| Edwardsville to Shotley Bridge | 4,020.86 mi (6,470.94 km) |
| Edwardsville to Shrewsbury | 4,047.94 mi (6,514.54 km) |
| Edwardsville to Sidcup | 4,195.52 mi (6,752.04 km) |
| Edwardsville to Sidmouth | 4,087.37 mi (6,577.98 km) |
| Edwardsville to Sileby | 4,109.93 mi (6,614.30 km) |
| Edwardsville to Sittingbourne | 4,222.74 mi (6,795.85 km) |
| Edwardsville to Skegness | 4,152.03 mi (6,682.05 km) |
| Edwardsville to Skelmersdale | 4,023.50 mi (6,475.20 km) |
| Edwardsville to Skipton | 4,040.37 mi (6,502.35 km) |
| Edwardsville to Sleaford | 4,128.20 mi (6,643.69 km) |
| Edwardsville to Slough | 4,166.39 mi (6,705.15 km) |
| Edwardsville to Small Heath | 4,089.34 mi (6,581.15 km) |
| Edwardsville to Smethwick | 4,084.09 mi (6,572.71 km) |
| Edwardsville to Snaresbrook | 4,187.18 mi (6,738.61 km) |
