| Edwardsville to Sesena | 4,405.29 mi (7,089.63 km) |
| Edwardsville to Sestao | 4,327.86 mi (6,965.02 km) |
| Edwardsville to Sevilla | 4,397.07 mi (7,076.40 km) |
| Edwardsville to Sevilla La Nueva | 4,381.79 mi (7,051.81 km) |
| Edwardsville to Silla | 4,581.60 mi (7,373.38 km) |
| Edwardsville to Silleda | 4,113.44 mi (6,619.94 km) |
| Edwardsville to Sitges | 4,612.51 mi (7,423.11 km) |
| Edwardsville to Socuellamos | 4,475.00 mi (7,201.81 km) |
| Edwardsville to Soller | 4,706.66 mi (7,574.64 km) |
| Edwardsville to Solsona | 4,572.24 mi (7,358.31 km) |
| Edwardsville to Son Servera | 4,741.56 mi (7,630.80 km) |
| Edwardsville to Sonseca | 4,407.61 mi (7,093.37 km) |
| Edwardsville to Sopelana | 4,326.68 mi (6,963.12 km) |
| Edwardsville to Soria | 4,403.95 mi (7,087.48 km) |
| Edwardsville to Suances | 4,277.73 mi (6,884.34 km) |
