| Edwardsville to Santa Ursula | 4,177.75 mi (6,723.44 km) |
| Edwardsville to Santander | 4,287.59 mi (6,900.20 km) |
| Edwardsville to Santany | 4,741.35 mi (7,630.46 km) |
| Edwardsville to Santiago de Compostela | 4,093.85 mi (6,588.41 km) |
| Edwardsville to Santiago del Teide | 4,165.48 mi (6,703.69 km) |
| Edwardsville to Santiponce | 4,387.78 mi (7,061.44 km) |
| Edwardsville to Santomera | 4,599.60 mi (7,402.35 km) |
| Edwardsville to Santona | 4,303.62 mi (6,926.01 km) |
| Edwardsville to Santurce-Antiguo | 4,326.08 mi (6,962.15 km) |
| Edwardsville to Sarria | 4,147.88 mi (6,675.37 km) |
| Edwardsville to Sauzal | 4,178.74 mi (6,725.03 km) |
| Edwardsville to Sedavi | 4,580.39 mi (7,371.42 km) |
| Edwardsville to Segorbe | 4,560.28 mi (7,339.07 km) |
| Edwardsville to Segovia | 4,357.29 mi (7,012.37 km) |
| Edwardsville to Senmanat | 4,613.34 mi (7,424.45 km) |
