| Edwardsville to Sangeorgiu de Mures | 5,287.75 mi (8,509.81 km) |
| Edwardsville to Sangeorz-Bai | 5,256.35 mi (8,459.28 km) |
| Edwardsville to Sannicolau Mare | 5,173.59 mi (8,326.10 km) |
| Edwardsville to Santana | 5,192.53 mi (8,356.57 km) |
| Edwardsville to Satu Mare | 5,175.26 mi (8,328.78 km) |
| Edwardsville to Scobinti | 5,331.76 mi (8,580.63 km) |
| Edwardsville to Scornicesti | 5,384.58 mi (8,665.64 km) |
| Edwardsville to Sebes | 5,284.15 mi (8,504.01 km) |
| Edwardsville to Seini | 5,190.84 mi (8,353.85 km) |
| Edwardsville to Sfantu-Gheorghe | 5,366.19 mi (8,636.05 km) |
| Edwardsville to Sibiu | 5,312.52 mi (8,549.67 km) |
| Edwardsville to Sighetu Marmatiei | 5,203.23 mi (8,373.79 km) |
| Edwardsville to Sighisoara | 5,314.79 mi (8,553.32 km) |
| Edwardsville to Simeria | 5,269.45 mi (8,480.36 km) |
| Edwardsville to Sinaia | 5,382.65 mi (8,662.55 km) |
