| Edwardsville to Spello | 5,002.93 mi (8,051.44 km) |
| Edwardsville to Spilamberto | 4,873.11 mi (7,842.51 km) |
| Edwardsville to Spilimbergo | 4,881.62 mi (7,856.21 km) |
| Edwardsville to Spinea | 4,879.42 mi (7,852.67 km) |
| Edwardsville to Spoleto | 5,013.16 mi (8,067.90 km) |
| Edwardsville to Spoltore | 5,084.48 mi (8,182.68 km) |
| Edwardsville to Spresiano | 4,871.09 mi (7,839.27 km) |
| Edwardsville to Squinzano | 5,329.63 mi (8,577.21 km) |
| Edwardsville to Statte | 5,289.60 mi (8,512.79 km) |
| Edwardsville to Stezzano | 4,774.23 mi (7,683.39 km) |
| Edwardsville to Strada | 4,923.72 mi (7,923.96 km) |
| Edwardsville to Stradella | 4,782.44 mi (7,696.59 km) |
| Edwardsville to Striano | 5,171.93 mi (8,323.42 km) |
| Edwardsville to Subiaco | 5,064.49 mi (8,150.52 km) |
| Edwardsville to Sulmona | 5,093.18 mi (8,196.67 km) |
