| Edwardsville to Sestu | 5,005.43 mi (8,055.46 km) |
| Edwardsville to Settimo Torinese | 4,718.66 mi (7,593.95 km) |
| Edwardsville to Seveso | 4,754.01 mi (7,650.84 km) |
| Edwardsville to Sezze | 5,081.41 mi (8,177.73 km) |
| Edwardsville to Siano | 5,177.76 mi (8,332.81 km) |
| Edwardsville to Siena | 4,935.13 mi (7,942.33 km) |
| Edwardsville to Signa | 4,906.83 mi (7,896.77 km) |
| Edwardsville to Silea | 4,878.15 mi (7,850.63 km) |
| Edwardsville to Silvi Paese | 5,079.51 mi (8,174.68 km) |
| Edwardsville to Sinalunga | 4,955.58 mi (7,975.23 km) |
| Edwardsville to Siniscola | 4,979.32 mi (8,013.44 km) |
| Edwardsville to Sinnai | 5,010.10 mi (8,062.98 km) |
| Edwardsville to Siracusa | 5,365.44 mi (8,634.84 km) |
| Edwardsville to Solaro | 4,752.98 mi (7,649.19 km) |
| Edwardsville to Soliera | 4,861.17 mi (7,823.29 km) |
