| Edwardsville to Sacile | 4,873.33 mi (7,842.87 km) |
| Edwardsville to Sala Consilina | 5,232.19 mi (8,420.40 km) |
| Edwardsville to Salemi | 5,226.89 mi (8,411.87 km) |
| Edwardsville to Salerno | 5,185.70 mi (8,345.57 km) |
| Edwardsville to Salo | 4,811.13 mi (7,742.77 km) |
| Edwardsville to Salsomaggiore Terme | 4,820.31 mi (7,757.54 km) |
| Edwardsville to Saluzzo | 4,726.17 mi (7,606.04 km) |
| Edwardsville to Salzano | 4,876.07 mi (7,847.27 km) |
| Edwardsville to Samarate | 4,740.91 mi (7,629.76 km) |
| Edwardsville to San Benedetto del Tronto | 5,053.19 mi (8,132.33 km) |
| Edwardsville to San Biagio di Callalta | 4,880.15 mi (7,853.84 km) |
| Edwardsville to San Bonifacio | 4,848.74 mi (7,803.29 km) |
| Edwardsville to San Casciano in Val di Pesa | 4,915.43 mi (7,910.62 km) |
| Edwardsville to San Cataldo | 5,291.84 mi (8,516.39 km) |
| Edwardsville to San Cesareo | 5,057.16 mi (8,138.71 km) |
