| Edmond to Southern Pines (North Carolina) | 1,013.17 mi (1,630.53 km) |
| Edmond to Southfield (Michigan) | 891.40 mi (1,434.57 km) |
| Edmond to Southgate (Michigan) | 885.51 mi (1,425.09 km) |
| Edmond to Southlake (Texas) | 188.16 mi (302.81 km) |
| Edmond to Spanaway (Washington) | 1,507.94 mi (2,426.79 km) |
| Edmond to Spanish Fork (Utah) | 832.92 mi (1,340.45 km) |
| Edmond to Spanish Lake (Missouri) | 451.14 mi (726.05 km) |
| Edmond to Spanish Springs (Nevada) | 1,244.48 mi (2,002.80 km) |
| Edmond to Sparks (Nevada) | 1,246.39 mi (2,005.88 km) |
| Edmond to Spartanburg (South Carolina) | 873.98 mi (1,406.54 km) |
| Edmond to Spearfish (South Dakota) | 696.59 mi (1,121.06 km) |
| Edmond to Speedway (Indiana) | 672.88 mi (1,082.89 km) |
| Edmond to Spencer (Iowa) | 530.54 mi (853.83 km) |
| Edmond to Spokane (Washington) | 1,317.80 mi (2,120.79 km) |
| Edmond to Spokane Valley (Washington) | 1,309.79 mi (2,107.91 km) |
