| East Niles to Southern Pines (North Carolina) | 2,213.82 mi (3,562.80 km) |
| East Niles to Southfield (Michigan) | 1,963.26 mi (3,159.57 km) |
| East Niles to Southgate (Michigan) | 1,965.34 mi (3,162.91 km) |
| East Niles to Southlake (Texas) | 1,253.30 mi (2,016.99 km) |
| East Niles to Spanaway (Washington) | 830.37 mi (1,336.35 km) |
| East Niles to Spanish Fork (Utah) | 515.09 mi (828.96 km) |
| East Niles to Spanish Lake (Missouri) | 1,593.72 mi (2,564.85 km) |
| East Niles to Spanish Springs (Nevada) | 299.12 mi (481.38 km) |
| East Niles to Sparks (Nevada) | 293.79 mi (472.82 km) |
| East Niles to Spartanburg (South Carolina) | 2,077.80 mi (3,343.90 km) |
| East Niles to Spearfish (South Dakota) | 1,015.98 mi (1,635.06 km) |
| East Niles to Speedway (Indiana) | 1,804.77 mi (2,904.50 km) |
| East Niles to Spencer (Iowa) | 1,374.43 mi (2,211.94 km) |
| East Niles to Spokane (Washington) | 853.21 mi (1,373.10 km) |
| East Niles to Spokane Valley (Washington) | 853.87 mi (1,374.18 km) |
