| East Lansing to Southern Pines (North Carolina) | 588.75 mi (947.50 km) |
| East Lansing to Southfield (Michigan) | 64.96 mi (104.54 km) |
| East Lansing to Southgate (Michigan) | 75.17 mi (120.97 km) |
| East Lansing to Southlake (Texas) | 965.10 mi (1,553.18 km) |
| East Lansing to Spanaway (Washington) | 1,861.48 mi (2,995.77 km) |
| East Lansing to Spanish Fork (Utah) | 1,412.41 mi (2,273.05 km) |
| East Lansing to Spanish Lake (Missouri) | 405.49 mi (652.57 km) |
| East Lansing to Spanish Springs (Nevada) | 1,828.20 mi (2,942.20 km) |
| East Lansing to Sparks (Nevada) | 1,832.37 mi (2,948.91 km) |
| East Lansing to Spartanburg (South Carolina) | 556.41 mi (895.46 km) |
| East Lansing to Spearfish (South Dakota) | 972.12 mi (1,564.48 km) |
| East Lansing to Speedway (Indiana) | 223.73 mi (360.06 km) |
| East Lansing to Spencer (Iowa) | 539.96 mi (868.98 km) |
| East Lansing to Spokane (Washington) | 1,626.56 mi (2,617.69 km) |
| East Lansing to Spokane Valley (Washington) | 1,617.33 mi (2,602.84 km) |
