| East Islip to University Place (Washington) | 2,452.90 mi (3,947.57 km) |
| East Islip to Upland (California) | 2,455.97 mi (3,952.51 km) |
| East Islip to Upper Arlington (Ohio) | 522.18 mi (840.36 km) |
| East Islip to Upper Grand Lagoon (Florida) | 1,013.45 mi (1,630.99 km) |
| East Islip to Upper Montclair (New Jersey) | 53.65 mi (86.34 km) |
| East Islip to Urbana (Illinois) | 789.77 mi (1,271.01 km) |
| East Islip to Urbana (Maryland) | 240.11 mi (386.42 km) |
| East Islip to Urbana (Ohio) | 557.17 mi (896.68 km) |
| East Islip to Urbandale (Iowa) | 1,070.23 mi (1,722.37 km) |
| East Islip to Utica (New York) | 194.46 mi (312.95 km) |
| East Islip to Uvalde (Texas) | 1,693.15 mi (2,724.87 km) |
| East Islip to Vacaville (California) | 2,570.64 mi (4,137.04 km) |
| East Islip to Vadnais Heights (Minnesota) | 1,047.20 mi (1,685.30 km) |
| East Islip to Vail (Arizona) | 2,153.45 mi (3,465.65 km) |
| East Islip to Valdosta (Georgia) | 884.98 mi (1,424.24 km) |
