| East Islip to Southern Pines (North Carolina) | 510.45 mi (821.49 km) |
| East Islip to Southfield (Michigan) | 533.99 mi (859.37 km) |
| East Islip to Southgate (Michigan) | 528.37 mi (850.33 km) |
| East Islip to Southlake (Texas) | 1,423.95 mi (2,291.62 km) |
| East Islip to Spanaway (Washington) | 2,448.32 mi (3,940.19 km) |
| East Islip to Spanish Fork (Utah) | 2,006.86 mi (3,229.73 km) |
| East Islip to Spanish Lake (Missouri) | 912.46 mi (1,468.46 km) |
| East Islip to Spanish Springs (Nevada) | 2,425.34 mi (3,903.20 km) |
| East Islip to Sparks (Nevada) | 2,429.41 mi (3,909.76 km) |
| East Islip to Spartanburg (South Carolina) | 621.47 mi (1,000.17 km) |
| East Islip to Spearfish (South Dakota) | 1,569.64 mi (2,526.09 km) |
| East Islip to Speedway (Indiana) | 691.03 mi (1,112.11 km) |
| East Islip to Spencer (Iowa) | 1,137.99 mi (1,831.42 km) |
| East Islip to Spokane (Washington) | 2,212.04 mi (3,559.94 km) |
| East Islip to Spokane Valley (Washington) | 2,202.85 mi (3,545.15 km) |
