| East Islip to Silver Firs (Washington) | 2,428.77 mi (3,908.72 km) |
| East Islip to Silver Spring (Maryland) | 235.57 mi (379.12 km) |
| East Islip to Silver Springs Shores (Florida) | 944.29 mi (1,519.69 km) |
| East Islip to Silverdale (Washington) | 2,455.03 mi (3,950.99 km) |
| East Islip to Silverton (Oregon) | 2,489.46 mi (4,006.41 km) |
| East Islip to Simi Valley (California) | 2,508.64 mi (4,037.26 km) |
| East Islip to Simpsonville (South Carolina) | 645.40 mi (1,038.68 km) |
| East Islip to Sioux City (Iowa) | 1,201.10 mi (1,932.98 km) |
| East Islip to Sioux Falls (South Dakota) | 1,217.73 mi (1,959.75 km) |
| East Islip to Skokie (Illinois) | 758.95 mi (1,221.41 km) |
| East Islip to Sleepy Hollow (New York) | 43.89 mi (70.64 km) |
| East Islip to Slidell (Louisiana) | 1,176.08 mi (1,892.71 km) |
| East Islip to Smithfield (North Carolina) | 456.37 mi (734.46 km) |
| East Islip to Smithfield (Utah) | 1,990.72 mi (3,203.75 km) |
| East Islip to Smithville (Missouri) | 1,131.99 mi (1,821.76 km) |
