| East Islip to Security-Widefield (Colorado) | 1,671.65 mi (2,690.26 km) |
| East Islip to Sedalia (Missouri) | 1,072.18 mi (1,725.51 km) |
| East Islip to Sedro-Woolley (Washington) | 2,427.53 mi (3,906.73 km) |
| East Islip to Seguin (Texas) | 1,589.33 mi (2,557.78 km) |
| East Islip to Selden (New York) | 12.46 mi (20.05 km) |
| East Islip to Selma (Alabama) | 957.18 mi (1,540.43 km) |
| East Islip to Selma (California) | 2,492.49 mi (4,011.28 km) |
| East Islip to Selma (Texas) | 1,606.33 mi (2,585.14 km) |
| East Islip to Seminole (Florida) | 1,043.62 mi (1,679.55 km) |
| East Islip to Seven Hills (Ohio) | 444.31 mi (715.05 km) |
| East Islip to Seven Oaks (South Carolina) | 634.82 mi (1,021.65 km) |
| East Islip to Severn (Maryland) | 215.91 mi (347.48 km) |
| East Islip to Severna Park (Maryland) | 211.98 mi (341.15 km) |
| East Islip to Sevierville (Tennessee) | 653.96 mi (1,052.45 km) |
| East Islip to Seymour (Indiana) | 684.48 mi (1,101.57 km) |
